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Additionally, the impact of the loss of GLP-2R signaling on the intestinal response to increased food intake with cold stress was maintained in the duodenum and jejunum of male mice aged to 25 weeks, demonstrating conservation of this response with age (Supplementary Fig
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& Csala, M
The positive feedback loop established by these interactions not only exacerbates local inflammation but also contributes to the dysfunction of Sertoli and Leydig cells, ultimately leading to impaired spermatogenesis and erectile dysfunction (3, 27)
