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NPs have demonstrated potential to deliver therapeutic moieties or contrast agents to the target site with minimal side effects to healthy tissue [25]
According to multiple studies, the therapeutic dose of Accutane is 1 to 2 mg per kilogram of body weight per day
The authors acknowledge this limitation
N Engl J Med 1988
Further supporting this, Lock and colleagues demonstrated that glutathione protects against 2-chloropropionic acid (CPA)-induced cerebellar toxicity by preserving thiol redox equilibrium and potentially interacting with NMDA receptor-mediated pathways
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