Peptide-spectrum match (PSM) validation was carried out using the percolator algorithm to ensure reliable identifications
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To advance clinical application, future research should develop multimodal biomarker panels by integrating technologies such as mass spectrometry imaging, spatial transcriptomics, and single-cell lipidomics, combined with artificial intelligence to define a distinct ferroptosis signature in neurodegeneration
Moreover, simplified experimental paradigms often fail to capture the complex, multifactorial nature of human neurodegeneration, including chronic inflammation, metabolic dysfunction, and cumulative injury [569571]
Synthetic BPC-157, a pentadecapeptide comprising 15 amino acids isolated from the much larger BPC protein, has been found to retain many of the healing properties of its parent molecule