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however, caution should be exercised because there are very few reports of pediatric patients with BRAFV600E mutant tumors successfully treated with Vemurafenib, which has shown to be safe in clinical trials of melanoma, but there are significant side effects with its use, ranging from rash, arthralgia, nausea, squamous cell carcinoma and liver damage

Briefly, samples were stained with 10 M YO-PRO-1 (Thermo Fisher Scientific, Barcelona, Spain) and 0.5 M PI (Thermo Fisher Scientific, Barcelona, Spain) to study viability, apoptosis, and mortality

BMC Public Health 22(1), 440

Advances in Peptide Research, 22 (3), 121-134

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