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The interplay between GLP-1-based therapies, the gut microbiome, and MASLD/MASH in type 2 diabetes mellitus: A narrative review
Compared to PEGylation (which only prolongs circulation) or antibody conjugation (which carries immunogenic risk), membrane-coating achieves ~ 23-fold higher renal accumulation efficiency and reduces systemic toxicity by avoiding protein corona-induced nonspecific adsorption
Microbes insidefrom diversity to function: the case of Akkermansia
Improvements in several metabolic parameters were documented, including decreased postprandial insulin, and a profile of gut hormones favouring control of appetite (increased fasting GLP-1 and GIP, increased postprandial GLP-1 and a decreased ratio of ghrelin:GLP-1), compared to a low-fat diet [11]
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