The treatment of DKD has been largely dependent on the management of hyperglycemia and hypertension
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The pathogenesis of sarcopenia is complex and multifaceted: the chronic catabolic condition, increased energy expenditure, reduced appetite, side effects of multiple therapies, alterations in circulating levels of hormones, low protein synthesis, and the presence of ascites or portosystemic shunts are all factors contributing to muscle atrophy in cirrhotic patients [23]
The Pickart 2018 review documented effects on collagen synthesis, anti-inflammatory signaling, nerve regeneration, and stem cell recruitment (Pickart et al., Int J Mol Sci, 2018)
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