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While many PSMA-targeted ADCs have entered the clinical pipelineincluding SHR-4394, which carries an undisclosed payload and is currently recruiting patients for its first phase I clinical trial (NCT06783829)many have failed to advance beyond phase I/II clinical trials due to modest PSA response rates, inadequate survival benefit, and significant toxicity 80,81
[5] [6] The oral formulation (Rybelsus) reports nausea in 1120% of patients according to its SmPC
When a pair finishes mating, they give off warning calls to let other frogs know they are temporarily unavailable to mate
A synaptic model of memory: long-term potentiation in the hippocampus
Very dark urine or yellow skin: These can mean liver or gallbladder problems
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