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Injection site reactions represent the primary side effect, and these are typically manageable with proper technique
Yes, though rarely
The major pools of folate derivatives are found in the liver followed by the kidneys where they are distributed between the cytosol and the mitochondria
The 5,10-methenyl-THF is converted to 10-formyl-THF, which then feeds into the folate cycle, by the MTFDH1 encoded enzyme as described in N 10 -Formyltetrahydrofolate Synthesis section above
Representative image of Laurdan staining in A-498 cells treated or not with combined heparinases/chondroitinase (0.1 U/mL)
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