In human clinical trials, individuals ingesting ME-3 for two weeks gained a remarkable 49% increase in the ratio between reduced to oxidized glutathione
The intranasal forms of methylcobalamin, vitamin B12, should be administered at least 1 hour before or 1 hour after ingestion of hot food or liquids
Lab and animal studies build on this as well, showing the extract reduces inflammatory signals, boosts a protein important for barrier health (filaggrin), and has anti-itch/antibacterial activity (including against C.acnes, the bacteria linked to breakouts)
Early work focused on the hGH fragment 177191, which was later modified by adding a tyrosine residue, leading to the development of AOD 9604
Applications in Research As a standard diluent for peptide and protein reconstitution Preparation of injectable-grade research compounds for in vitro or ex vivo studies Investigation of peptide and biologic stability following reconstitution Formulation testing and solvent compatibility studies Multi-use experimental workflows requiring bacteriostatic protection Specifications Summary Purity: Manufactured to specification Appearance: Clear, colourless sterile solution Solvent Type: Bacteriostatic aqueous diluent Preservative: Benzyl alcohol 0.9% (w/v) Solubility: Fully miscible with water and aqueous buffers Storage: Controlled room temperature Pack Size: 10 ml Handling, Use & Stability Use aseptic technique when accessing vial contents Avoid contact with non-sterile surfaces Do not use if solution becomes cloudy or discoloured Seal vial promptly after use to maintain sterility Avoid exposure to excessive heat or prolonged light Do not freeze Precautions & Notes Not all peptides or biologics are compatible with benzyl alcohol
