Mitochondrial ROS can act as triggers for ferroptosis, while the presence of mitochondrial antioxidant systems, comprised of enzymatic and non-enzymatic antioxidants, can mitigate ferroptosis [50, 57, 60,61,62,63,64,65,66]
Chin J Clin Res 2017;30:7-10
Subtle improvements often appear after 48 sessions (roughly 48 weeks), with more noticeable changes around 1012 weeks
The traditional route
It is interesting to note that other post-acute infection syndromes (PAIS) and some neuropsychiatric diseases such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), depression (especially the atypical/immunometabolic subtype (IMD) [86]) and others also have fatigue as a leading clinical symptom, which may serve as a model for investigating the mechanisms of fatigue and drawing conclusions regarding therapeutic options in long COVID