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In patients with locally advanced, metastatic, and/or refractory solid tumors and hematological malignancies, CB839 is being evaluated in open-label phase I clinical trials (NCT02071862, NCT02071888, NCT02771626)
The relative abundance of Erysipelatoclostridium was increased in vehicle-treated mice that underwent the WD to LD switch (WD/LD-V) relative to the two control groups (LD/LD-V and WD/WD-V) but was not increased in 5A-1MQ-treated mice that underwent the same diet switch (WD/LD-T)
(Figures 1B, C)
(i) help regenerate vitamins C and E
doi: 10.3389/fphar.2020.00557 234 CecChinatoVTryniszewskaEMaZMVaccariMBoassoATsaiW-Pet al
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