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TRIUMPH-2 (1,152 patients with obesity and type 2 diabetes) showed up to 20.8% weight loss and up to 1.6 percentage points of HbA1c reduction at the 12mg dose over 80 weeks

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Diabetic Retinopathy In the SUSTAIN-6 trial, an increase in DRP complications, defined as a composite of need for retinal photocoagulation or treatment with intravitreal agents or vitreous hemorrhage or diabetes-related-blindness, was reported for semaglutide compared to placebo (hazard ratio 1.76

Physiol Rev 98:11691203 Yang M, Vousden KH (2016) Serine and one-carbon metabolism in cancer

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