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The result: excessive sedation, respiratory depression risk, and morning impairment far beyond what either substance produces alone
IGF-1 was identified in 1957 by Salmon and Daughaday, and originally designated sulfation factor because of its ability to stimulate sulphate incorporation into rat cartilage
As per the UK SmPC, the dose is escalated every 4 weeks to reach the target dose of 2.4 mg, with the option to delay a step by 4 weeks if not tolerated
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