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TLR1, TLR2 and TLR4 activation results in augmented mitochondrial ROS production following recruitment of mitochondria to macrophage phagosomes, leading the way to increased mitochondrial and cellular ROS generation (West et al., 2011)

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Am J Epidemiol 1994

Genetic predispositions in pathways like GIPR (rs1800437), and FTO (rs9939609) may help explain individual variation, though they do not predict exact response