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Heres what I found: Bariatric surgery leads to greater, more durable weight loss and comorbidity reduction compared to GLP-1s GLP-1s offer substantial but less sustained comorbidity benefit with higher discontinuation rates (up to 50% at 35 yrs) GLP-1s do not eliminate the need for bariatric surgery in severe obesity Total weight loss trends higher for bariatric surgery, and real-world GLP-1 effectiveness is generally lower than clinical trial results (a significant finding that deserves its own post) Bariatric surgery is generally more effective than GLP-1s for long-term diabetes remission and cardiovascular risk reduction GLP-1s are associated with higher ongoing costs and are less cost-effective than bariatric surgery long-term The take home: GLP-1s are a valuable addition but dont replace bariatric procedures for patients with severe obesity or those requiring durable, substantial weight loss with co-morbidity reduction

We can help you navigate your weight loss journey, offering a balanced perspective that goes beyond just the scale to help you achieve a healthier, happier version of yourself

Note: I do not treat KP, please see my colleagues at Clinic Cutis

Ozempic should be combined with other positive lifestyle changes to maximize your weight loss success

Therefore, rat GGT may provide insight into human GGT expression and regulation