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Semaglutide can cause dehydration due to gastrointestinal side effects, potentially leading to acute kidney injury

Injection of GLP-1 directly into the central nucleus of the amygdala (CeA) of rats results in CTA (Kinzig et al., 2002) whereas injection into the PVN reduces food intake without eliciting CTA (McMahon and Wellman, 1998)