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Diabetes 53 , 654662 (2004) T
A Phase 1a, blinded, placebo-controlled, randomized, single- and multiple-ascending-dose study was done to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple doses of orforglipron
At the highest dose, about 42 per cent of patients experienced nausea, while more than 32 per cent reported diarrhoea
By the time he arrived, though, leptin had started to disappoint in trials
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