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Subcutaneous administration near the injury site provides both high local concentration and some systemic distribution as the peptide migrates to areas of damage throughout the body
Most users notice initial effects within 7-14 days, with pain reduction being the earliest indicator
Finally, some commonly used drugs (e.g., glucocorticoids and GLP-1RAs) can also affect intra-portal insulin levels that modulate the GH/IGF-I axis either by increasing or decreasing hepatic GH sensitivity, as reflected by the discordant GH and IGF-I levels
Circulating hormones were measured using enzyme-linked immunosorbent assay (ELISA
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