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Traditional proteomics-based methods, such as N-terminomics 37,38,39 and proteomic identification of protease cleavage sites 40 , are well suited for global analyses of protease activity but can be low throughput and may lack the sensitivity to detect low-frequency, yet biologically perturbative, off-target cleavage events
Cavezzi A, Troiani E, Corrao S
Once in the body, glutathione acts as a powerful intracellular antioxidant and plays a central role in detoxification pathways, particularly in the liver
Therapeutic strategies targeting SSG show promise: Recombinant TRX or N-acetylcysteine reduces ischemic reperfusion injury by restoring endothelial NOS activity (100), while tanshinone IIA, a traditional Chinese medicine component, protects against myocardial ischemia via PKM2 glutathionylation at Cys423/424(101)
Plants 14 (3), 352
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