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A Phase 2 trial (a mid-stage human trial, typically involving a few hundred participants) published in the New England Journal of Medicine in 2023 reported an average weight loss of about 24% at 48 weeks with the highest dose
Rybelsus Rybelsus (semaglutide) is a brand-name GLP-1 agonist that helps lower blood sugar in adults with Type 2 diabetes
They also reported feeling more tired unsurprisingly and spent more time snoring during the night
I recommend a consistent weight loss of 1.5 to 2 lbs per week as a target
It might improve your quality of life, emotional wellbeing or sense of achievement The original trial of semaglutide did not focus on this bundle of benefits, but further follow-ups show additional benefits associated with the medication
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