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Participants received weekly subcutaneous injections with standard dose escalation protocols to minimize gastrointestinal side effects

Joint and muscle discomfort are occasionally reported with GLP-1 medications, but they are not among the most common side effects

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[1] Managing Increased Urination While Taking GLP-1 Medications If you are experiencing increased urination whilst taking GLP-1 medication, several practical strategies can help manage this symptom whilst ensuring your treatment remains effective: Monitor your fluid intake : Maintain adequate hydration (NHS recommends 6-8 cups or glasses of fluid per day for most adults) but avoid excessive fluid consumption unless medically advised

This is the same reason you should never freeze reconstituted tirzepatide or other GLP-1 peptides after mixing