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Within the mitochondria itaconate inhibits the succinate dehydrogenase (SDH) complex which results in reduced flow of carbons through the TCA cycle as well as inhibition of oxidative phosphorylation since TCA cycle SDH is also complex II of the electron transport chain

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I'm grateful that I live at a time when the biology and pathophysiology of obesity are understood, and we have a treatment that is safe and effective

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