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Senescent cells accumulate over time and are characterized by altered gene expression, resistance to apoptosis, and secretion of inflammatory mediators collectively referred to as the senescence-associated secretory phenotype (SASP)

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Adipose tissue itself produces pro-inflammatory moleculesTNF-alpha and IL-6that impair lymphatic endothelial function and increase capillary permeability, allowing more fluid to escape into tissues

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However, newer real-world evidence from electronic health records and observational studies continues to support their overall safety