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Cagrilintide is engineered around that problem: it is a modified, lipidated peptide that acts as a dual amylin and calcitonin receptor agonist and is stable enough for once-weekly subcutaneous dosing

By clearing these cells, FOXO4-DRI reduces inflammation and restores tissue function, potentially mitigating age-related decline and promoting healthier aging

Phase 2 trials showed up to 24.2% weight loss at 48 weeks, more than any other GLP-1 class medication tested so far