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It is becoming increasingly obvious that treating obesity also requires a multimodal approach that combines lifestyle interventions, pharmacotherapy, and bariatric surgery to achieve the tailored weight loss and metabolism goals needed for long-term health gain

Lancet 368 , 10961105 (2006)

Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells

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Hippocampal glutathione depletion with enhanced iron level in patients with mild cognitive impairment and Alzheimers disease compared with healthy elderly participants