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In animal studies, this medication has been found to raise the risk of thyroid C-cell tumors, but it is not known if this applies to humans
A 2018 study in Dermatologic Therapy found that 38% of patients experienced rebound hyperpigmentation within 812 weeks of discontinuing hydroquinone monotherapy, likely because melanocytes compensate for reduced tyrosinase activity by upregulating MITF (microphthalmia-associated transcription factor), the master regulator of melanocyte differentiation
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"Understanding Diabetes -- Diagnosis and Treatment"
Results start to become noticeable within a few weeks, with full effects visible after a couple of months
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