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doi: 10.1371/journal.pone.0071108 70 GravdalKKirsteKHGrzelakKKirubakaranGTLeissnerPSaliouAet al
GLP-1R agonists demonstrate potential to treat Wolfram syndrome in human preclinical models
For instance, in January 2025, Nacuity Pharmaceuticals, Inc., was presented with the Fast Track designation for NPI-001 (N-acetylcysteine amide) tablets from the U.S
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Immunofluorescence staining also showed a marked increase in the number of Ki-67-positive cells and a decrease in the nuclear content of -H2AX and P21 after FOXO4-DRI treatment (Figures 4B,C)
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