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The carboxyl group of the glycine part chelates with the two copper ions, with the hydroxyl oxygen binding to CuB at a distance of 2.82 and the carbonyl oxygen binding to CuA at a distance of 2.66
While GLP-1 clearly affects appetite centers in the brain, adding GIP agonism might influence different neural circuits related to food reward, energy expenditure, or metabolic regulation
10.1016/j.biopha.2021.112115 52 YangF.TongJ.LiH.ChenJ.DaiL
Endocrinology 162:bqab091 Gorini F, Vassalle C (2022) Selenium and selenoproteins at the intersection of type 2 diabetes and thyroid pathophysiology
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This figure is arithmetic for research modeling, not a recommended dose the 100 mcg of each amount itself is a community convention, not a validated human dose
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