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Berberine also directly influences fat metabolism, acting as an anti-adipogenic agent by suppressing the regulation of transcription factors vital for fat tissue growth, such as peroxisome proliferator-activated receptor gamma (PPARG), CCAAT enhancer binding protein (C/EBP), and sterol response element binding protein-1c (SREBP-1c) (AR

Compared to age-matched controls, insulin resistance in the brains of PD patients is independent of peripheral insulin resistance and manifests as severe abnormalities in brain insulin signal transduction

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Extended half-life (approximately 6-8 days)

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