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However, a few considerations are worth noting
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[7] [8] Prescription and administration: Once B12 deficiency is confirmed, GPs prescribe hydroxocobalamin injections according to standardised protocols: Standard loading regimen: 1mg intramuscularly three times weekly for two weeks Neurological involvement: 1mg intramuscularly on alternate days until no further improvement Maintenance therapy: 1mg every three months for life in pernicious anaemia or malabsorption conditions (or every two months if there was neurological involvement) Injections are typically administered by practice nurses at GP surgeries
Clinical data indicate an average weight loss of 20.9% at the highest dose, which may be advantageous for patients needing significant weight reduction
Scalp conditions affecting barrier integrity may increase absorption and associated risks
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