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Semaglutide is often considered more potent for weight loss and blood sugar control

Weighing side effects, convenience, and the reason you want to lose weight helps you and your clinician decide

And with weight gain comes the return of insulin resistance. If you discontinue the medication, lifestyle interventions can partially preserve insulin sensitivity improvements after you stop taking the meds, says Silvana Obici, MD, the chief of the division of endocrinology at Stony Brook Medicine and the medical director of the Stony Brook University Hospital Diabetes Center in New York

Your body does not distinguish between fat and muscle when it needs energy, so without deliberate protein intake, you can lose both

References: Wegovy (semaglutide) injection and tablets Prescribing Information