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Most short-term studies (812 weeks) show mild or no side effects, but chronic use safety requires ongoing medical supervision
Continuous Use There is limited research on optimal cycling strategies (periods of use followed by breaks) versus continuous use
Systematic reviews and meta-analyses of randomised controlled trials suggest that berberine may modestly reduce fasting blood glucose, HbA1c (a marker of long-term glucose control), and post-meal glucose levels in people with type 2 diabetes or non-diabetic hyperglycaemia (prediabetes)
It also inhibits the production of melanin
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