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Description

Wu et al., 2019)

Retatrutides Phase 2 monotherapy weight loss (~24.2% at 48 weeks) is numerically larger than cagrilintides (~10.8% at 26 weeks), but those come from different trials, durations, and doses, and cagrilintides strongest data are as the CagriSema combination

Possible mechanisms include inhibition of stearoyl-CoA desaturase-1 activity, -oxidation of fatty acids, and increased storage in the body tissues (49)