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The three compounds can be sourced and reconstituted separately, which allows independent dosing but adds cold-chain items and sterile draws
Prx3 homodimer has a redox-sensitive cysteine that upon reaction with H 2 O 2 is oxidized to Cys-SOH, which then reacts with neighboring Cys-SH of the other subunit to form an intermolecular disulfide that can be readily reduced by thioredoxin reductase 2 (TrxRD2
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CJC-1295, animal model Alba et al., 2006 (Endocrinology): once-daily CJC-1295 normalized growth in a GHRH-knockout mouse, supporting the GHRH-receptor mechanism
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