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doi: 10.1016/j.eclinm.2024.102726

Upon GLP-1 binding to its receptor GLP1R on pancreatic beta cells, a signaling cascade is initiated, leading to the activation of adenylyl cyclase and the production of cAMP), which activates protein kinase A (PKA) enhancing insulin gene transcription and insulin secretion 81

Yu et al

3 Extensively publicized reports of ocular adverse events, such as nonarteritic anterior ischemic optic neuropathy (NAION), have been challenging to assess due to confounding health factors and conflicting evidence

At standard split spacing (3 to 4 days), the accumulation effect is modest and generally well-tolerated because each individual dose is proportionally smaller