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100% achieved 5% Weight loss was dose-dependent: 4mg (-17.1%), 8mg (-22.8%), 12mg (-24.2%) at 48 weeks Results appeared early (visible by week 4) and continued throughout the 48-week trial Beyond weight: significant improvements in blood pressure, lipids, liver fat, and glycemic control Investigational Drug: Retatrutide is not FDA-approved

Nemeth C, Humpeler S, Kallay E, Mesteri I, Svoboda M, Rgelsperger O, Ekmekcioglu C (2011) Decreased expression of the melatonin receptor 1 in human colorectal adenocarcinomas

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Namely, sodiumglucose cotransporter 2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP1RAs) have demonstrated efficacy for reducing major adverse cardiac events (MACE) in several studies [6,7,8,9,10]