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The MDPI review reports that short sleep duration is associated with increased ghrelin and decreased leptin, hormones involved in hunger and satiety. Together, these findings show that sleep quality and duration influence how the body adapts to a calorie deficit

Pre-existing conditions like gastroparesis or irritable bowel syndrome can extend your adjustment period by 1-2 weeks, while healthy digestive function often means faster symptom resolution

Appetite suppression often accompanies early nausea, creating the desired metabolic signal but sometimes arriving too intensely during the adaptation phase

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