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Oxidation of Pro generates NADP/NADPH cycling or redox balance (Kishor et al., 2005) that in turn may regulate the reduction of GSSG to GSH via GSH reductase (Anjum et al., 2010, 2012a

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Therefore, upregulation of GGT in tumor cells provides a potential mechanism to resist oxidative stress and foster tumor progression

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In leptin-resistant-obese mice, CR (1 month) reduced the levels of malondialdehyde (MDA) in the serum and increased the level of peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 protein), which is a member of a family of transcription coactivators with a central role in the regulation of energy metabolism) (Waldman et al., 2018)