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Yuan T, Meijia L, Rong C, Jian Y, Lijun H
McGraw-Hill / Lange rxlist.com (Onglyza ) Keywords Linagliptin Trade Name: Tragenta Drug Class: oral hypoglycemics Mechanism of Action: An inhibitor of dipeptidyl peptidase-4 (DPP-4), a protease that degrades the incretin GLP-1 Pharmacokinetics: biliary tract excretion - unique elimination route amongst the DPP-4 inhibitors useful for Type II diabetic patients with reduced renal function
As shown in Figure 4, there are 11 enzymes relevant to glycolysis/gluconeogenesis upregulated in this dataset, including phosphofructokinase, aldolase, glyceraldehyde-3-phosphate dehydrogenase, phosphoglycerate kinase, enolase, and pyruvate kinase
In concert with the E2 ubiquitin-conjugating enzyme UBCH5a, glutathionylated OTUB1 interacts with SLC7A11 and prevents proteasomal degradation (Figure 4)
Saw no significant change in his mood/appetite
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