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The newest GLP-1 drug, tirzepatide, was first approved in 2022 as Mounjaro for treatment of diabetes and later approved in 2024 as Zepbound for obesity

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On 4th December 2023 , Roche acquired Carmot Therapeutics for US$ 2.7 Billion for their GLP agonists

A more recent randomized, double-blind, placebo-controlled study in 30 patients with type 2 diabetes found that intravenous infusion of 600 mg of lipoic acid improved the response to the endothelium-dependent vasodilator acetylcholine but not to the endothelium-independent vasodilator, glycerol trinitrate (63)