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However, due to concerns for safety, quality, and effectiveness of compounded GLP1RAs, the American Diabetes Association (ADA) has issued guidance recommending switching individuals to different FDA-approved medications to achieve and maintain individualized glucose-lowering, weight management, and/or cardiovascular and kidney risk reduction goals when supply or access is limited [75]

"These drugs have such a cost that it is not possible to completely mitigate the ramifications," he said

PMC: Comparative Safety of GLP-1/GIP Co-Agonists Versus GLP-1 Receptor Agonists for Weight Loss. New England Journal of Medicine: Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes. PMC: Who Wins the Battle Against Obesity

The combination is studied because the three molecules act on complementary pathways in published research models