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Eming SA, et al
GLP-1 Case Study Name: Richard J., a 58-year-old male Medical History: Type 2 Diabetes Mellitus (diagnosed 7 years ago) Obesity (BMI 35 kg/m) Hypertension (well-controlled on an ACE inhibitor) Mild diabetic retinopathy Current Medications: Metformin 1000 mg twice daily, glimepiride 2 mg once daily, and lisinopril 20 mg once daily Clinical Presentation Richard presents a routine follow-up
Under hyperglycemic conditions, SGLT2-dependent SGK1 activation drives canonical tubular epithelial cell pyroptosis, as confirmed by GSDMD-mediated pore formation and the release of IL-1, IL-18, and LDH (167)
The FDAs approval for the pill version of Wegovy came just a few days after the European Medicines Agency gave a positive opinion for a higher dose of the drug to be injected
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