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FXR in liver physiology: Multiple faces to regulate liver metabolism

Abstract Rational assembly of small molecule libraries for purposes of drug discovery requires an efficient approach in which the synthesis of bioactive compounds is enabled so that numerous structurally related compounds of a similar basic formulation can be derived

[1] [2] This weekly dosing schedule is consistent with other long-acting incretin-based therapies and is designed to maintain stable plasma drug concentrations throughout the week, minimising peaks and troughs that could exacerbate side effects

Warning: risk of thyroid C-cell tumors In rodents, semaglutide causes thyroid C-cell tumors

Cell 152 , 532542 (2013) Rasmussen, S