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The spectrum of MASLD ranges from simple steatosiswhere fat accumulation causes minimal inflammationto metabolic dysfunction-associated steatohepatitis (MASH, formerly NASH), characterized by inflammation and liver cell damage that can progress to cirrhosis
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The usual mechanistic explanation is that the GHRH arm drives somatotroph cAMP signalling while the GHRP arm additionally attenuates somatostatin tone, so the two are acting on different limbs of the same axis rather than competing for one receptor
Clinical confirmation and verification of result reproducibility remain a mandatory next step
Dan Bell joined Marken in 2003 and is Senior Vice President, Innovation & Strategic Operations
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