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In addition, the possibility to manipulate SLC25A39 and/or to regulate the amount of GSH that enters mitochondria also offers the opportunity to study the importance of mitochondrial GSH in more detail, especially in mitochondria-rich tissues like liver or kidney
L-gamma-Glutamyl-L-cysteinyl-glycine disulfide
Upregulated: collagen synthesis genes (COL1A1, COL3A1), antioxidant genes (SOD1, SOD3), DNA repair genes (GADD45A) Downregulated: inflammatory cytokines (IL-6, TNF-), metalloproteinases (MMP-2, MMP-9), pro-fibrotic mediators Net effect: shift from tissue destruction and inflammation toward repair and remodeling This breadth of gene modulation is unusual for a single tripeptide and has generated significant research interest in fields ranging from dermatology to neuroscience
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Genome-wide gene expression modulation studies
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