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Extended Data Figure 5 ECL3, TM7, TM1 and ICL3 may be associated with GLP-1R biased agonism

This effect seems to be dose-related, as patients receiving 5 mg daily showed a mean reduction of about 100 cells/mcL, and those receiving 2.5 mg daily did not have a decrease in lymphocyte count

These steps are essential to managing and preventing semaglutide-induced rash, allowing you to continue your treatment with minimal skin issues

Dietary modifications can significantly impact symptom management

Semaglutide was dosed for the full period, while antibody dosing with the -MSTN and -ActA antibodies was started in Week 2 as an add-on to semaglutide and dosed through Week 12 (and was presumed to have more durable actions due to the extended half-life of the antibodies)