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In the in vitro comparison experiments, treated groups were seeded at 2 10 cells/well and exposed to either 200 M CORT (1% DMSO) or 1 mM NE for 24 h, while control groups were seeded at 1 10 cells/well and received a medium replacement containing 1% DMSO

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Cells also harbor multiple parallel, GPX4-independent antiferroptotic pathways, many of which rely on endogenous radical-trapping antioxidants (RTAs) that directly quench lipid radicals (Fig