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Supplementation of folic acid is also important for patients on certain medicines, such as methotrexate for rheumatoid arthritis, as these medications can reduce folate in the body
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Some individuals achieve 20%+ weight loss while others experience more modest results, partly reflecting these underlying genetic differences
It is important to consider factors such as the patients baseline UTI risk, the role of concurrent conditions like diabetes and obesity (which independently increase UTI risk), and the overall health profile of the study population
Based on extrapolated benefits from weight reduction, this combination may be considered in patients with obesity and OA who are not candidates for incretin therapies
