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Ann Rheum Dis (2022)
Our study has important implications for our understanding of enzymatically active and inactive glutaredoxins and could be useful for the design and optimization of artificial glutaredoxins, glutaredoxin-coupled fluorescent redox sensors and transition-state inhibitors
9th edn (Saunders, 2000)
Formulation design therefore prioritizes: Gastrointestinal protection via liposomal encapsulation Phospholipid carriers that support membrane-compatible uptake Intracellular delivery efficiency as a design objective (not a slogan) Process choices that reduce first-pass / GI breakdown of the reduced form Core objective: maximize defensible systemic availability of reduced glutathione-supported by encapsulation metrics and retention data, not only phospholipid presence on a label
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