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*Correspondence: Hang Lin, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Tissue Engineering and Regenerative Medicine, a section of the journal Frontiers in Bioengineering and Biotechnology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

GSH is synthesized de novo in the brain by astrocytes and research has demonstrated increased GSH synthesis during oxidative stress-related toxicity in vitro , proposing in vivo synthesis of this antioxidant might be sufficient to not detect significant changes (14)

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References 1.Seiwerth S, Brcic L, Vuletic LB, Kolenc D, Aralica G, Misic M, Zenko A, Drmic D, Rucman R, Sikiric P